MKRN1 Antibody

  • MKRN1 Antibody

    from ProSci
    CatalogueID : 29-840

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Target MKRN1
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB
Clone Polyclonal
Unit 0.1 mg
Format Antibody is lyophilized in PBS buffer with 2% sucrose. Add 100 μL of distilled water. Final antibody concentration is 1 mg/ml. Powder
Concentration Lyophilized
Description The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the MKRN1 gene is the ancestral founder of this gene family.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. MKRN1 (makorin, ring finger protein, 1)
Cite This Product ProSci cat# 29-840 RRID:AB_10910385
Company ProSci, Inc
Accession Number NP_038474
Immunogen Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MKRN1.
Molecular Weight 16 kDa, 17 kDa