MED28 Antibody

  • MED28 Antibody

    from ProSci
    CatalogueID : 4731

  • Contact Vendor

Target med28
Species Cross Reactivity Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC, IF
Target Species Homo sapiens
Target/Molecule Synonym MED28 Antibody: Mediator of RNA polymerase II transcription subunit 28, magicin, EG1
Format Liquid, MED28 Antibody is supplied in PBS containing 0.02% sodium azide
Concentration 1 mg/mL
NCBI Gene Aliases EG1, DKFZp434N185, 1500003D12Rik, magicin
Description MED28 Antibody: The mediator complex is a multi-protein transcriptional co-activator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factor. One of the proteins in this complex is MED28, also known as Magicin. MED28 is expressed in many cell lines and tissues. It has been shown that a down-regulation of MED28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell differentiation and conversely its over-expression represses expression of SMC genes. MED28 can also form a ternary complex with Grb2 and Merlin, the neurofibromatosis 2 tumor suppressor protein, indicating that MED28 may play a role in Merlin's tumor suppressive activity. MED28 has also been recently identified as an HIV dependency factor (HDF), suggesting that MED28 may be an important drug target in HIV treatment. At least two isoforms of MED28 are known to exist
Cite This Product ProSci cat# 4731 RRID:AB_10907715
Company ProSci
Type Antibody
Accession Number NP_079481
Immunogen MED28 antibody was raised against a 17 amino acid synthetic peptide from near the center of human MED28
Isotype IgG
Molecule Name MED28 mediator complex subunit 28
Clonality Polyclonal