SATB1 Antibody

  • SATB1 Antibody

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    CatalogueID : 4631

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Target Znf800
Species Cross Reactivity Rattus norvegicus, Mus musculus, Gallus gallus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC, IF
Target Species Homo sapiens
Target/Molecule Synonym SATB1 Antibody: DNA-binding protein SATB1, Special AT-rich sequence-binding protein 1
Format SATB1 Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
Description SATB1 Antibody: Human special AT-rich sequence-binding protein-1 (SATB1) is a nuclear matrix/scaffold-associated region DNA-binding protein, predominantly expressed in the thymus and pre-B cells. Like its homolog SATB2, SATB1 selectively binds double-stranded, special AT-rich DNA sequences in which one strand exclusively consists of well-mixed A, T, and C nucleotides. SATB1 contains a dimerization domain that shares similarity with the PDZ motif, identified as an indispensable element for high-affinity binding of SATB1 to DNA. SATB1 constitutes a functional nuclear architecture that has a 'cage-like' protein distribution surrounding heterochromatin and regulates gene expression through chromatin remodeling/HDAC (histone deacetylase complex) and transcription factors recruitment. SATB1 functions as a 'genome organizer' essential for proper T-cell development. Recent studies show that SATB1 is necessary for breast cancer cells to become metastatic, and when ectopically expressed in non-metastatic cells, can induce invasive activity in vivo. At least two isoforms of SATB1 are known to exist
Cite This Product ProSci cat# 4631 RRID:AB_10904423
Company ProSci
Type Antibody
Accession Number Q01826
Immunogen SATB1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human SATB1
Isotype IgG
Molecule Name SATB1 SATB homeobox 1
Clonality Polyclonal