Rabbit Anti-Human ALAS1 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Human ALAS1 Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 49-260

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Target alaS1
Species Cross Reactivity Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB, IHC
Target Species Homo sapiens
Target/Molecule Synonym ALAS1, ALAS, ALAS-H, ALAS3, ALASH, EC 2.3.1.37, MIG4, 5-aminolevulinic acid synthase mitochondrial precursor, nonspecific, alas1
Unit 0.05 mg
Format Purification: Protein G ColumnFormulation: Weight: 50 µg Concentration: 0.5 mg/ml
Description Principal Names: 5-amino levulinate synthase, ALAS, ALAS-H, ALAS-3, Delta-ALA synthetase,Migration inducing protein 4(MIG4); Official Gene Symbol: ALAS1 Gene ID: 211(human) Gene Map Locus: 3p21.1(human) ALAS-1 (EC 2.3.1.37) is a nuclear-encoded mitochondrial matrix enzymecatalyzing the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA. It regulates the first and rate-limiting step of heme biosynthetic pathway. It is one of the two isoforms of ALAS and is a pyridoxal-5 phosphate dependant housekeeping enzyme. It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins. ALAS1 in liver undergoes negative feedback regulation by heme. Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression. ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders. ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.Immunogen: ALAS1 antibody was raised against a portion of amino acids 480-530 of ALAS1. (Human)Application: ALAS1 antibody can be used for detection of ALAS1 by WB (1 - 3 µg/ml), IHC-parafin (5 µg/ml).Buffer: ALAS1 antibody is supplied in PBS, 0.2% gelatin, 0.05% sodium azide.Storage: ALAS1 antibody can be stored at 4ºC for short term storage, and -20ºC for long term storage.
Cite This Product ProSci cat# 49-260 RRID:AB_1945038
Company ProSci, Inc
Type Polyclonal Antibody
Isotype IgG