Rabbit Anti-Human APP Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Human APP Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 49-566

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Target APP
Species Cross Reactivity Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC, IP, IF
Target Species Homo sapiens
Target/Molecule Synonym APP, A4, AAA, ABETA, ABPP, AD1, APPI, CTFGAMMA, CVAP, PN-II, PN2, PREA4, a/beta, abeta, alzheimer's disease amyloid a4 protein, amyloid beta, AMYLOID BETA A4 PRECURSOR PROTEIN, amyloid beta peptide, amyloid beta precursor protein, app, beta amyloid, cvap, protease nexin II
Unit 0.05 mg
Format Purification: Immunoaffinity ChromatographyFormulation: Weight: 50 µg Concentration: 1 mg/ml
Description Beta amyloid, often abbreviated as A-beta, is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In some cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased production of amyloid. Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Furthermore, presenilin-1 might be gamma-secretase.Immunogen: APP antibody was raised against aa 1-14 of APP. (Human)Application: APP antibody can be used for detection of APP by WB, IP, ELISA, IF, IHC-parafin (5 µg/ml).Buffer: APP antibody is supplied in 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.Storage: APP antibody can be stored at 4ºC or -20ºC. Avoid repeated freezing and thawing..
Cite This Product ProSci cat# 49-566 RRID:AB_1945153
Company ProSci, Inc
Type Polyclonal Antibody
Uniprot ID Q28748