Rabbit Anti-APC Polyclonal Antibody, Unconjugated

  • Rabbit Anti-APC Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 48-437

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Target Apc
Species Cross Reactivity Mus musculus, Rattus norvegicus, Gallus gallus, Ovis aries
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications IHC
Target/Molecule Synonym APC, DP2, DP2.5, DP3, FAP, FPC, GS, adenomatous polyposis coli protein, apc, apc tumor suppressor gene, dp2, dp2.5, fpc, gs
Unit 0.05 mg
Format Purification: Immunoaffinity ChromatographyFormulation: Weight: 50 µg Volume: 250 µl Concentration: 0.2 mg/ml
Description Although the metabolic function of the tumor suppressor APC gene is not known, it is involved in maintaining cytoplasmic levels of the Wingless (Wg)/Wnt effector (Armadillo)/beta-catenin at a steady state. During development, beta-catenin is involved in cell growth and axis patterning. APC binds beta-catenin preventing it to act as a transcription factor and targets it for destruction. Mutations in the APC gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy such as Gardner syndrome and colorectal cancer.Immunogen: APC antibody was raised against a peptide from the C-terminus of APC. (Human)Application: APC antibody can be used for detection of APC by IHC-parafin (10 µg/ml).Buffer: APC antibody is supplied in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.Storage: APC antibody can be stored at 4ºC, avoid freezing.
Cite This Product ProSci cat# 48-437 RRID:AB_1945115
Company ProSci, Inc
Type Polyclonal Antibody