Rabbit Anti-Human APOBEC3G Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Human APOBEC3G Polyclonal Antibody, Unconjugated

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    CatalogueID : 3257

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Species Cross Reactivity Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC
Target Species Homo sapiens
Target/Molecule Synonym APOBEC3G Antibody:
Format APOBEC3G Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
NCBI Gene Aliases ARP-9, dJ494G10.1, CEM-15, CEM15, ARCD, ARP9, bK150C2.7, FLJ12740
Description APOBEC3G Antibody: The Apoliprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytidine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates. Similar to TRIM5α which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection as at least two isoforms, APOBEC3G and to a lesser extent APOBEC3F, can be incorporated HIV-1 virions and induce hypermutation in the newly synthesized viral DNA and thus destabilize the viral genome. This innate mechanism of retroviral resistance is counteracted by the HIV-1 Vif protein by inducing the ubiquitization and degradation of APOBEC3G; a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity
Cite This Product ProSci cat# 3257 RRID:AB_712972
Company ProSci
Type Antibody
Accession Number NP_068594
Immunogen APOBEC3G antibody was raised against a synthetic peptide corresponding to 15 amino acids near the amino-terminus of human APOBEC3G
Isotype IgG
Molecule Name APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
Clonality Polyclonal