Rabbit Anti-Bacterial Anthrax EF Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Bacterial Anthrax EF Polyclonal Antibody, Unconjugated

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    CatalogueID : 3419

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Target Edema factor
Species Cross Reactivity Archaea (Species unspecified)
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA
Target/Molecule Synonym Anthrax Edema Factor Antibody: Anthrax EF
Format Liquid, Anthrax Edema Factor Antibody is supplied in PBS containing 0.02% sodium azide
Concentration 1 mg/mL
Description Anthrax Edema Factor Antibody: Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. EF is a calmodulin and Ca++-dependent adenylate cyclase responsible for the edema seen in the disease. It is thought to benefit the B. anthracis bacteria by inhibiting cells of the host immune system
Cite This Product ProSci cat# 3419 RRID:AB_712887
Company ProSci
Type Antibody
Accession Number P40136
Immunogen Anthrax Edema Factor antibody was raised against a synthetic peptide corresponding to 16 amino acids near the carboxy terminus of the Anthrax edema factor protein
Isotype IgG
Molecule Name Calmodulin-sensitive adenylate cyclase
Clonality Polyclonal