Rabbit Anti-Bacterial Anthrax LF Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Bacterial Anthrax LF Polyclonal Antibody, Unconjugated

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    CatalogueID : 3415

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Target Lethal factor
Species Cross Reactivity Archaea (Species unspecified)
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA
Target/Molecule Synonym Anthrax Lethal Factor Antibody: Anthrax LF
Format Anthrax Lethal Factor Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
Description Anthrax Lethal Factor Antibody: Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. LF is the primary toxin of anthrax and functions as a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family near their amino terminus, interfering with MAPK signaling and inducing apoptosis
Cite This Product ProSci cat# 3415 RRID:AB_712888
Company ProSci
Type Antibody
Accession Number P15917
Immunogen Anthrax lethal factor antibody was raised against a synthetic peptide corresponding to 16 amino acids in the middle of the Anthrax lethal factor protein
Isotype IgG
Molecule Name Lethal factor
Clonality Polyclonal