Rabbit Anti-BAG-1 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-BAG-1 Polyclonal Antibody, Unconjugated

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    CatalogueID : 3869

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Target BAG1
Species Cross Reactivity Rattus norvegicus, Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB
Target Species Homo sapiens
Target/Molecule Synonym BAG-1 Antibody: Bcl-2-binding athanogene-1, receptor-associated protein 46, RAP46
Format BAG-1 Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
NCBI Gene Aliases HAP, RAP46
Description BAG-1 Antibody: Bcl-2-associated athanogene 1 (BAG-1) was first identified as an anti-apoptotic bcl-2-binding protein. Later it was found to bind the molecular chaperones Hsp70 and Hsc70 through its carboxy-terminal sequence (termed the Bag domain), resulting in the inhibition of the refolding activity of these chaperones. It is thought that by binding and inhibiting these molecular chaperones, BAG-1is able to modulate the expression level of proteins requiring chaperones to fold correctly. One such group of proteins that are affected is glucocorticoid receptors. Other reports have suggested that the level of BAG-1 expression correlates with the aggressiveness of various cancers. Multiple isoforms of BAG-1 are known to exist
Cite This Product ProSci cat# 3869 RRID:AB_2275521
Company ProSci
Type Antibody
Accession Number NP_004314
Immunogen BAG-1 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human BAG-1
Isotype IgG
Molecule Name BAG1 BCL2-associated athanogene
Clonality Polyclonal