Rabbit Anti-Bik Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Bik Polyclonal Antibody, Unconjugated

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    CatalogueID : 3819

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Target BIK
Species Cross Reactivity Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, ICC, WB, IF
Target Species Homo sapiens
Target/Molecule Synonym Bik Antibody: Bcl-2-interacting killer, apoptosis inducer NBK
Format Bik Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
NCBI Gene Aliases NBK, BIP1, BP4
Description Bik Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by the activation of proteolytic enzymes termed caspases. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such protein BIK was recently identified as an endoplasmic reticulum (ER)-residing pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family that stimulates mitochondrial release of cytochrome c following p53 induction of apoptosis. A significant fraction of BIK is found as an ER transmembrane protein, with most of the protein facing the cytosol. Restricting BIK to the ER membrane by replacing the transmembrane region with that of the ER-selective membrane anchor of cytochrome b resulted in a decreased cytochrome c release from mitochondria and a corresponding drop in cell death. Recent evidence suggests that BIK cooperates with NOXA, another BH3-only protein, to somehow enhance the activation of Bax to stimulate the rapid release of cytochrome c from mitochondria
Cite This Product ProSci cat# 3819 RRID:AB_735316
Company ProSci
Type Antibody
Accession Number CAG30276
Immunogen BIK antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human BIK
Isotype IgG
Molecule Name BIK BCL2-interacting killer (apoptosis-inducing)
Clonality Polyclonal