Rabbit Anti-Bmf (NT) Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Bmf (NT) Polyclonal Antibody, Unconjugated

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    CatalogueID : 3031

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Target BMF
Species Cross Reactivity Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, ICC, WB
Target Species Homo sapiens
Target/Molecule Synonym Bmf Antibody:
Format Bmf Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
NCBI Gene Aliases FLJ00065
Description Bmf Antibody: Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program. Bmf is constitutively expressed in many tissues
Cite This Product ProSci cat# 3031 RRID:AB_203148
Company ProSci
Type Antibody
Accession Number NP_277038
Immunogen EndoG antibody was raised with a synthetic peptide corresponding to 15 amino acids near the amino terminus of human EndoG
Isotype IgG
Molecular Weight 25 kDa
Molecule Name BMF Bcl2 modifying factor
Clonality Polyclonal