BDNF Antibody

  • BDNF Antibody

    from ProSci
    CatalogueID : XP-5108

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Target BDNF
Species Cross Reactivity Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB
Clone Polyclonal
Target/Molecule Synonym Abrineurin, Brain Derived Neurotrophic Factor, MGC34632, Neurotrophin
Unit 0.1 mg
Format A sterile filtered antibody solution (1 mg/mL) was lyophilized from 0.5X PBS pH 7.2. Powder
Concentration Lyophilized
Description Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes NGF, NT3, and NT4. All neurotrophins have six conserved cysteine residues and share a 55% sequence identity at the amino acid level. BDNF is a potent neurotrophic factor that supports the growth and survivability of nerve and/or glial cells. BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro, including neural crest and placode derived sensory neurons, dopaminergic neurons in the substantia nigra, basal forebrain cholinergic neurons, hippocampal neurons, and retinal ganglial cells. BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields, raising the possibility that BDNF has paracrine or even autocrine actions on neurons as well as non neuronal cells. Expression of BDNF is reduced in both Alzheimers and Huntington disease patients. In addition, functional studies showed that age-associated changes in BDNF-mediated pathways can enhance inflammation and increase myocardial injury after myocardial infarction in the aging heart. Anti-Human BDNF
Cite This Product ProSci cat# XP-5108 RRID:AB_713019
Company ProSci, Inc
Type Polyclonal Antibody
Source/Expression System Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hBDNF (human Brain-Derived Neurotrophic Factor).