Rabbit Anti-Human Calretinin Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Human Calretinin Polyclonal Antibody, Unconjugated

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    CatalogueID : 48-446

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Target Calretinin
Species Cross Reactivity Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB, IHC
Target Species Homo sapiens
Target/Molecule Synonym CALB2, CAB29, CAL2, CALRETININ, CR, calretinin
Unit 0.05 mg
Format Purification: Immunoaffinity ChromatographyFormulation: Weight: 50 µg Volume: 250 µl Concentration: 0.2 mg/ml
Description Calbindin 2 (calretinin), closely related to calbindin 1, is an intracellular calcium-binding protein belonging to the troponin C superfamily. Calbindin 1 is known to be involved in the vitamin-D-dependent calcium absorption through intestinal and renal epithelia, while the function of neuronal calbindin 1 and calbindin 2 is poorly understood. The sequence of the calbindin 2 cDNA reveals an open reading frame of 271 codons coding for a protein of 31,520 Da, and shares 58% identical residues with human calbindin 1. Calbindin 2 contains five presumably active and one presumably inactive calcium-binding domains. Comparison with the partial sequences available for chick and guinea pig calbindin 2 reveals that the protein is highly conserved in evolution. The calbindin 2 message was detected in the brain, while absent from heart muscle, kidney, liver, lung, spleen, stomach and thyroid gland. There are two additional forms of alternatively spliced calbindin 2 mRNAs encoding C-terminally truncated proteins. Exon 7 can splice to exon 9, resulting in a frame shift and a translational stop at the second codon of exon 9, and encoding calretinin-20k. Exon 7 can also splice to exon 10, resulting in a frame shift and a translational stop at codon 15 of exon 10, and encoding calretinin-22k. The truncated proteins are able to bind calcium.Immunogen: Calretinin antibody was raised against recombinant full length Calretinin. (Mouse)Application: Calretinin antibody can be used for detection of Calretinin by WB (2.5 - 5 µg/ml), IHC-parafin (5 µg/ml).Buffer: Calretinin antibody is supplied in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.Storage: Calretinin antibody can be stored at 4ºC, avoid freezing.
Cite This Product ProSci cat# 48-446 RRID:AB_1945439
Company ProSci, Inc
Type Polyclonal Antibody