Rabbit Anti-CARMA1 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-CARMA1 Polyclonal Antibody, Unconjugated

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    CatalogueID : 3189

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Target Card11
Species Cross Reactivity Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC, IF
Target Species Homo sapiens
Target/Molecule Synonym CARMA1 Antibody:
Format CARMA1 Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
NCBI Gene Aliases MGC133069, BIMP3, CARMA1
Description CARMA1 Antibody: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the IκK complex, thereby regulating activation of the NF-κB transcription factor. Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems
Cite This Product ProSci cat# 3189 RRID:AB_735334
Company ProSci
Type Antibody
Accession Number Q9BXL7
Immunogen CARMA1 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1
Isotype IgG
Molecule Name CARD11 caspase recruitment domain family, member 11
Clonality Polyclonal