Mouse Anti-Mouse Caspase-1 Monoclonal Antibody, Unconjugated, Clone...

  • Mouse Anti-Mouse Caspase-1 Monoclonal Antibody, Unconjugated, Clone 14F468

    from ProSci
    CatalogueID : 48-495

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Target Caspase-1
Species Cross Reactivity Mus musculus
Host Species Mus musculus
Target Tag/Conjugate Unconjugated
Applications WB, IHC
Clone Clone 14F468
Target Species Mus musculus
Target/Molecule Synonym CASP1, CASP-1, EC 3.4.22.36, ICE, IL-1BC, IL1BC, IL1BCE, P45, casp-1, casp1, caspase-1, ICE-like protease, il-1 beta converting enzyme, il-1bc, il1bc, il1bce, interleukin-1 beta convertase, interleukin-1 beta converting enzyme, interleukin-1 beta converting enzyme (ICE)-like protease
Unit 0.05 mg
Format Purification: Protein G ColumnFormulation: Weight: 50 µg Volume: 100 µl Concentration: 0.5 mg/ml
Description Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis (1). The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into tetramer to form the active enzyme. Caspase-1/ICE (IL-1b converting enzyme) is similar to the cell death gene CED-3 of Caenorhabditilis elegans and regulates multiple proinflammatory cytokines, including interleukin-1b and interferon-gamma-inducing factor. Caspase 1, also called interleukin-1 beta converting enzyme, is a cysteine C14 endopeptidase able to process pro-interleukin-1 beta into its active form. Caspase 1 is identical to Caenorhabditis elegans cell death gene ced-3 and may be involved in apoptotic signalling. Inhibition of caspase-1 in mice models extended survival and delayed appearance of neuronal inclusions and symptoms of Huntingdon disease.Immunogen: Caspase-1 monoclonal antibody was raised against a synthetic peptide corresponding to amino acids 371-390 of Caspase-1. (Human)Application: Caspase-1 antibody can be used for detection of Caspase-1 by WB (5 - 2 µg/ml), IHC-parafin.Buffer: Caspase-1 monoclonal antibody is supplied in PBS, 0.2% gelatin, 0.05% sodium azide.Storage: Caspase-1 monoclonal antibody can be stored at 4ºC or -20ºC, Avoid repeated freezing and thawing.
Cite This Product ProSci cat# 48-495 RRID:AB_1945485
Company ProSci, Inc
Type Monoclonal Antibody
Isotype IgG1
Uniprot ID P29452