Rabbit Anti-Casp-12 (lrg) Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Casp-12 (lrg) Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 3195

  • Contact Vendor

Target Casp12
Species Cross Reactivity Rattus norvegicus, Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC, IF
Target Species Mus musculus
Target/Molecule Synonym Caspase-12 Antibody: Large Caspase-12 large, Casp-12 lrg
Format Caspase-12 Antibody is supplied in PBS containing 0.02% sodium azide. (Large), Liquid
Concentration 1 mg/mL
Description Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues
Cite This Product ProSci cat# 3195 RRID:AB_735613
Company ProSci
Type Antibody
Accession Number CAA73532
Immunogen Caspase-12 antibody was raised against a synthetic peptide corresponding to amino acids within the large cleavage product of murine caspase-12
Isotype IgG
Molecule Name Casp12 caspase 12
Clonality Polyclonal