Rabbit Anti-Casp-12 (sml) Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Casp-12 (sml) Polyclonal Antibody, Unconjugated

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    CatalogueID : 3197

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Target Casp12
Species Cross Reactivity Rattus norvegicus, Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC
Target Species Mus musculus
Target/Molecule Synonym Caspase-12 Antibody: Small Caspase-12 small, Casp-12 sml
Format Caspase-12 Antibody is supplied in PBS containing 0.02% sodium azide. (Small), Liquid
Concentration 1 mg/mL
Description Caspase-12 Antibody: (Small)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues
Cite This Product ProSci cat# 3197 RRID:AB_735616
Company ProSci
Type Antibody
Accession Number CAA73532
Immunogen caspase-12 antibody was raised against a synthetic peptide corresponding to amino acids within. The small cleavage product of murine caspase-12
Isotype IgG
Molecule Name Casp12 caspase 12
Clonality Polyclonal