Rabbit Anti-Caspase-12 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Caspase-12 Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 49-614

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Target Caspase-12
Species Cross Reactivity Homo sapiens, Mus musculus, Rattus norvegicus
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB, IHC
Target/Molecule Synonym CASP12, CASP12P1, CASPASE-12, casp12, caspase 12
Unit 0.05 mg
Format Purification: PurifiedFormulation: Weight: 50 µg Concentration: 0.5 mg/ml
Description Caspases mediate essential key proteolytic events in inflammatory cascades and the apoptotic cell death pathway. Caspase 12 is involved in the apoptosis triggered by a stress on the endoplasmic reticulum. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer’s disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase 12 activation results in cell death in the absence of the cytochrome c-dependent pathway. Recently caspase-12 has been suggested to affect signaling pathways linking some G-protein coupled receptors to alphaIIbbeta3 activation. Caspase-12 is ubiquitously expressed in mouse tissues.Immunogen: Caspase-12 antibody was raised against amino acids 2-17 of Caspase-12. (Human)Application: Caspase-12 antibody can be used for detection of Caspase-12 by WB, IHC-parafin (10 µg/ml).Buffer: Caspase-12 antibody is supplied in PBS, 0.02% sodium azide.Storage: Caspase-12 antibody can be stored at 4ºC or -20ºC, Avoid repeated freezing and thawing.
Cite This Product ProSci cat# 49-614 RRID:AB_1945487
Company ProSci, Inc
Type Polyclonal Antibody