Rabbit Anti-Caspase-14 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Caspase-14 Polyclonal Antibody, Unconjugated

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    CatalogueID : 2509

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Target Casp14
Species Cross Reactivity Rattus norvegicus, Mus musculus, Protozoa (Species unspecified), Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC
Target Species Mus musculus
Target/Molecule Synonym Caspase-14 Antibody: Mini-interleukin-1 converting enzyme, Mini-ICE, MICE
Format Caspase-14 Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
NCBI Gene Aliases MGC123949, MGC123948, MICE, mini-ICE
Description Caspase-14 Antibody: Caspases are a family of cysteine proteases that can be divided into apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1b and IL-18. Caspase-14 is highly expressed in embryonic but not adult tissues. It is processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in the keratinocyte terminal differentiation, which is important for the formation of the skin barrier
Cite This Product ProSci cat# 2509 RRID:AB_735619
Company ProSci
Type Antibody
Accession Number NP_033939
Immunogen Caspase-14 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human caspase-14
Isotype IgG
Molecule Name Casp14 caspase 14
Clonality Polyclonal