Rabbit Anti-Mouse CBX4 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Mouse CBX4 Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 48-604

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Target Cbx4
Species Cross Reactivity Mus musculus
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC, IF
Target Species Mus musculus
Target/Molecule Synonym CBX4, HPC2, NBP16, PC2
Unit 0.05 mg
Format Purification: Immunoaffinity ChromatographyFormulation: Weight: 50 µg Concentration: 1 mg/ml
Description PC2 is the human homolog of the Drosophila 'Polycomb' (Pc) protein which has been identified as a gene family member associated with a cellular memory system that is responsible for the inheritance of gene activity by progeny cells. The human Pc homolog gene is more closely related to a Xenopus Pc homolog, XPc, than to a previously described human Pc homolog, CBX2 (hPc1). However, the hPc2 and CBX2/hPc1 proteins are shown to colocalize in interphase nuclei of human U-2 OS osteosarcoma cells, suggesting that the proteins are part of a common protein complex. The human protein is believed to function as a repressor of proto-oncogene activity and that interference with hPc2 function can lead to derepression of proto-oncogene transcription and subsequently to cellular transformation. Other reports describe PC2 as a protein that has SUMO E3 activity for the corepressors CtBP and CtBP2.Immunogen: CBX4 antibody was raised against aa 95-107 of CBX4. (Human)Application: CBX4 antibody can be used for detection of CBX4 by WB (1:1000 - 1:4000), ELISA (1:10000 - 1:40000), IF (1:100 - 1:400), IHC-parafin (2.5 µg/ml).Buffer: CBX4 antibody is supplied in 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.Storage: CBX4 antibody can be stored at 4ºC or -20ºC, Avoid repeated freezing and thawing.
Cite This Product ProSci cat# 48-604 RRID:AB_1945523
Company ProSci, Inc
Type Polyclonal Antibody