Rabbit Anti-CCR3 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-CCR3 Polyclonal Antibody, Unconjugated

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    CatalogueID : 1105

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Target CCR3
Species Cross Reactivity Rattus norvegicus, Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC, IF
Target Species Homo sapiens
Target/Molecule Synonym CCR3 Antibody: CC chemokine receptor 3, eosinophil eotaxin receptor
Format CCR3 Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
NCBI Gene Aliases CD193, CKR3, CMKBR3, CC-CKR-3, MGC102841
Description CCR3 Antibody: Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells. CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS. High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems. The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia. These results indicate CCR3 plays an important role in HIV infection of CNS
Cite This Product ProSci cat# 1105 RRID:AB_735648
Company ProSci
Type Antibody
Accession Number NP_847899
Immunogen CCR3 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human CCR3
Isotype IgG
Molecule Name CCR3 chemokine (C-C motif) receptor 3
Clonality Polyclonal