Rabbit Anti-APH1 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-APH1 Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 4003

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Target APH1A
Species Cross Reactivity Rattus norvegicus, Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC
Target Species Homo sapiens
Target/Molecule Synonym APH1 Antibody: Anterior pharynx defective 1, presenilin stabilization factor
Format APH1 Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
NCBI Gene Aliases CGI-78, APH-1A, APH-1, 6530402N02Rik
Description APH1 Antibody: APH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gamma-secretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma- and epsilon-sites and can lead to the accumulation of the Amyloid beta peptide (Abeta) cleavage product that is associated with Alzheimer's disease. APH1 exists in at least three distinct isoforms with APH1a as the principal isoform present in the gamma-secretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed
Cite This Product ProSci cat# 4003 RRID:AB_735567
Company ProSci
Type Antibody
Accession Number AAH08732
Immunogen APH1 antibody was raised against a 18 amino acid synthetic peptide from near the center of human APH1
Isotype IgG
Molecule Name APH1A anterior pharynx defective 1 homolog A (C. elegans)
Clonality Polyclonal