Rabbit Anti-Human APIP Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Human APIP Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 49-263

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Target apip
Species Cross Reactivity Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB, IHC
Target Species Homo sapiens
Target/Molecule Synonym APIP, APIP2, CGI-29, DJ179L10.2, MMRP19
Unit 0.05 mg
Format Purification: Protein G ColumnFormulation: Weight: 50 µg Concentration: 0.5 mg/ml
Description The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1) (1,2). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Recently, Cho et al (4) have identified a new Apaf-1 Interactiong Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.Immunogen: APIP antibody was raised against a full-length His-tagged recombinant APIP protein. of APIP. (Human)Application: APIP antibody can be used for detection of APIP by WB (1 - 2 µg/ml), IHC-parafin (10 µg/ml).Buffer: APIP antibody is supplied in PBS, 0.2% gelatin, 0.05% sodium azide.Storage: APIP antibody can be stored at 4ºC for short term storage, for long term storage aliquot and store at -20ºC . Avoid freeze thaw cycles.
Cite This Product ProSci cat# 49-263 RRID:AB_1945120
Company ProSci, Inc
Type Polyclonal Antibody
Isotype IgG