Rabbit Anti-Human BARD1 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Human BARD1 Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 49-656

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Target BARD1
Species Cross Reactivity Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, IHC
Target Species Homo sapiens
Target/Molecule Synonym BARD1, BARD-1, brca1-associated ring domain protein (bard1)
Unit 0.05 mg
Format Purification: Protein G ColumnFormulation: Weight: 50 µg Concentration: 1 mg/ml
Description BARD1 interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, BARD1 shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. The BARD1 protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. BARD1 may be the target of oncogenic mutations in breast or ovarian cancer.Immunogen: BARD1 antibody was raised against amino acids 108 to 124 of BARD1. (Human)Application: BARD1 antibody can be used for detection of BARD1 by ELISA (1:0 - 1:1000), IHC-parafin (10 µg/ml).Buffer: BARD1 antibody is supplied in PBS, 0.1% sodium azide.Storage: BARD1 antibody can be stored at -20ºC for long term storage, and 4ºC for short term storage.
Cite This Product ProSci cat# 49-656 RRID:AB_1945295
Company ProSci, Inc
Type Polyclonal Antibody