Rabbit Anti-Beclin-1 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Beclin-1 Polyclonal Antibody, Unconjugated

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    CatalogueID : 3613

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Target becn1
Species Cross Reactivity Rattus norvegicus, Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC
Target Species Homo sapiens
Target/Molecule Synonym Beclin-1 Antibody: Beclin-1, Coiled-coil myosin-like Bcl-2-interacting protein
Format Liquid, Beclin-1 Antibody is supplied in PBS containing 0.02% sodium azide
Concentration 1 mg/mL
NCBI Gene Aliases VPS30, ATG6, beclin1
Description Beclin-1 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6, is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death
Cite This Product ProSci cat# 3613 RRID:AB_735592
Company ProSci
Type Antibody
Accession Number AAH10276
Immunogen Beclin-1 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human Beclin-1
Isotype IgG
Molecule Name BECN1 beclin 1, autophagy related
Clonality Polyclonal