Rabbit Anti-CAND1 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-CAND1 Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 49-401

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Target CAND1
Species Cross Reactivity Mus musculus, Rattus norvegicus
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC, IP
Target/Molecule Synonym CAND1, DKFZP434M1414, FLJ10114, FLJ10929, FLJ38691, FLJ90441, KIAA0829, TIP120, TIP120A
Unit 0.05 mg
Format Purification: Delipidation and DefibrinationFormulation: Volume: 50 µl
Description CAND1 is also known as TIP120A, and TATA-binding protein-interacting protein 120A. The SCF complex consists of the invariable components Skp1, Cul1, and Rbx1 as well as a variable F-box protein, and functions as an E3 ubiquitin ligase. E3 ubiquitin ligases regulate various physiological processes. CAND1 binds to Cul1 and potentially regulates the SCF complex. CAND1 physically associates with Cul1 in the nucleus and this interaction is mediated by a central region of Cul1 distinct from its binding sites for Skp1 and Rbx1. CAND1 selectively binds to unneddylated CUL1 and is dissociated by CUL1 neddylation. CAND1 forms a ternary complex with CUL1 and ROC1.Immunogen: CAND1 antibody was raised against amino acids 11-24 of CAND1. (Human)Application: CAND1 antibody can be used for detection of CAND1 by WB (1:500 - 1:1000), IP, ELISA (1:2000 - 1:10000), IHC-parafin (1:500).Buffer: CAND1 antibody is supplied as neat serum, no preservative added.Storage: CAND1 antibody can be stored at -20ºC prior to opening. Aliquot contents and freeze at -20ºC or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
Cite This Product ProSci cat# 49-401 RRID:AB_1945454
Company ProSci, Inc
Type Polyclonal Antibody