Rabbit Anti-Beta-Catenin Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Beta-Catenin Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 50-229

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Target Beta-catenin
Species Cross Reactivity Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus laevis
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB
Unit 0.1 ml
Format Purification: Affinity purified
Description Beta-catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway (Ding and Dale, 2002; Polakis, 2000). The role of beta-catenin in these processes is thought regulated by the sequential phosphorylation of Ser29 Ser33, Ser37 and Thr41 by glycogen synthase kinase 3beta (GSK3beta) (Liu et al., 2002). This hyperphosphorylation promotes the ubiquitylation and targeted destruction of beta-catenin. Mutations in components of this phosphorylation regulated process that prevent beta-catenin hyperphosphorylation by GSK3beta are strongly associated with cancers (Wang et al., 2003; Polakis, 2000; Liu et al., 2002).Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33,37 of human beta-catenin.Application: The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will react with mouse, rat and Xenopus based on the fact that these species have 100% homology with the amino acid sequence used as antigen.Buffer: Beta-Catenin antibody is supplied as affinity purified polyclonal antibody, 100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.Storage: Beta-Catenin antibody can be stored at -20ºC and is stable at -20ºC for at least 1 year.
Cite This Product ProSci cat# 50-229 RRID:AB_1945331
Company ProSci, Inc
Type Polyclonal Antibody