Rabbit Anti-CXCR4 (EL) Polyclonal Antibody, Unconjugated

  • Rabbit Anti-CXCR4 (EL) Polyclonal Antibody, Unconjugated

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    CatalogueID : 1012

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Target CXCR4
Species Cross Reactivity Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IF
Target Species Homo sapiens
Target/Molecule Synonym CXCR4 Antibody:
Format CXCR4 Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
NCBI Gene Aliases LCR1, NPYY3R, WHIM, HM89, LAP3, NPYRL, FB22, D2S201E, NPYR, NPY3R, LESTR, HSY3RR, CD184
Description CXCR4 Antibody: Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites
Cite This Product ProSci cat# 1012 RRID:AB_203171
Company ProSci
Type Antibody
Accession Number NP_003458
Immunogen CXCR4 antibody was raised against a peptide corresponding to amino acids 182 to 196 in. The second extracellular loop (EL) of human CXCR4
Isotype IgG
Molecule Name CXCR4 chemokine (C-X-C motif) receptor 4
Clonality Polyclonal