Mouse Anti-Human AMACR Monoclonal Antibody, Unconjugated, Clone 2A10F3

  • Mouse Anti-Human AMACR Monoclonal Antibody, Unconjugated, Clone 2A10F3

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    CatalogueID : 32-107

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Target AMACR
Species Cross Reactivity Homo sapiens
Host Species Mus musculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC
Clone Clone 2A10F3
Target Species Homo sapiens
Target/Molecule Synonym RACE
Unit 0.1 ml
Format Formulation: Ascitic fluid containing 0.03% sodium azide. Purified antibody available at no extra cost.
Description AMACR (alpha-methylacyl-CoA racemase) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. AMACR can be used as a positive marker for PIN. Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4); also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.GI Number: 23600Immunogen: Purified truncated recombinant AMACR-His fusion protein expressed in E. Coli strain BL21 (DE3).Application: Western Blot:1:500 - 1:2,000 IHC(P):1:500 - 1:2,000 ELISA:Propose dilution 1:10,000. Determining optimal working dilutions by titration test.Positive Control 1: Cat. No. 1205 - Jurkat Cell LysateStorage: AMACR monoclonal antibody can be stored at -20ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product ProSci cat# 32-107 RRID:AB_1945069
Company ProSci, Inc
Type Monoclonal Antibody
Isotype IgG2b
Uniprot ID O09174