Rabbit Anti-Bcl-rambo Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Bcl-rambo Polyclonal Antibody, Unconjugated

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    CatalogueID : 3023

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Target Bcl2l13
Species Cross Reactivity Rattus norvegicus, Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC, IF
Target Species Homo sapiens
Target/Molecule Synonym Bcl-rambo Antibody: Bcl-2 like protein 13, Mil1
Format Bcl-rambo Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
NCBI Gene Aliases Bcl2-L-13, BCL-RAMBO, MIL1
Description Bcl-rambo Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways
Cite This Product ProSci cat# 3023 RRID:AB_735590
Company ProSci
Type Antibody
Accession Number AAH07658
Immunogen Bcl-rambo antibody was raised against a 15 amino acid synthetic peptide from near the center of human Bcl-rambo
Isotype IgG
Molecule Name BCL2L13 BCL2-like 13 (apoptosis facilitator)
Clonality Polyclonal