Rabbit Anti-LAMP-2 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-LAMP-2 Polyclonal Antibody, Unconjugated

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    CatalogueID : 3627

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Target Lamp2
Species Cross Reactivity Archaea (Species unspecified), Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, ICC, WB
Target Species Homo sapiens
Target/Molecule Synonym LAMP-2 Antibody: LAMP-2, Lysosome associated membrane protein 2
Format LAMP-2 Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
NCBI Gene Aliases LGP110, LAMPB, CD107b
Description LAMP-2 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). LAMP-2, a highly glycosylated protein associated with the lysosome, has recently been shown to be important in autophagy as mice deficient in this protein failed to convert autophagic vacuoles into vacuoles leading to impaired degradation of long-lived proteins. This correlates with the finding that human LAMP-2 deficiency causing Danon's disease is associated with the accumulation of autophagic material in striated myocytes. LAMP-2 exists in multiple isoforms
Cite This Product ProSci cat# 3627 RRID:AB_735339
Company ProSci
Type Antibody
Accession Number NP_054701
Immunogen LAMP-2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus ofhuman LAMP-2
Isotype IgG
Molecule Name LAMP2 lysosomal-associated membrane protein 2
Clonality Polyclonal