Rabbit Anti-CRTH2 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-CRTH2 Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 4029

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Target Ptgdr2
Species Cross Reactivity Rattus norvegicus, Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC, IF
Target Species Homo sapiens
Target/Molecule Synonym CRTH2 Antibody: Chemoattractant receptor-homologous molecule expressed on Th2 cells, GPR44
Format CRTH2 Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
NCBI Gene Aliases CRTH2, CD294, DL1R, DP2
Description CRTH2 Antibody: The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. At least two different isoforms of CRTH2 are known to exist
Cite This Product ProSci cat# 4029 RRID:AB_735742
Company ProSci
Type Antibody
Accession Number NP_004769
Immunogen CRTH2 antibody was raised against a 15 amino acid synthetic peptide from near the center of human CRTH2
Isotype IgG
Molecule Name GPR44 G protein-coupled receptor 44
Clonality Polyclonal