Rabbit Anti-Human GAD1 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Human GAD1 Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 49-276

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Target GAD1
Species Cross Reactivity Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB, IHC
Target Species Homo sapiens
Target/Molecule Synonym GAD1, EC 4.1.1.15, GAD, GAD-67, GAD67, gad1, gad67, glutamate decarboxylase, 67 kd isoform
Unit 0.05 mg
Format Purification: Protein G ColumnFormulation: Weight: 50 µg Concentration: 0.5 mg/ml
Description Principal Names: GAD1; Glutamate Decarboxylase 1; GAD67; Glutamic acid Decarboxylase 67; Official Gene Symbol: GAD1 Gene ID: 2571 (Human) Gene Map Locus: 2q31 (human) Glutamate Decarboxylase (EC 4.1.1.15) catalyzes the conversion of L-glutamic acid to GABA, a major inhibitory neurotransmitter in the CNS. GAD67, a 67KDa protein, is a neuronal isoform of this enzyme predominantly expressed in human Brain. It consists of Pyridoxal 5-phosphate binding site and conserved Cysteine residues which are vital for its activity and is inhibited due to phosphorylation. It has high binding affinity for the cofactor Pyridoxal-5phosphate and its role has been implicated in normal Palate development. It is found to be associated with childhood onset schizophrenia and craniofacial malformations and has been identified as a major auto antigen and an auto-reactive T-cell target in IDDM. Deficiency of this enzyme leads to pyridoxine dependency along with epilepsy. It also might play a role in stiff main syndrome.Immunogen: GAD1 antibody was raised against a KLH-conjugated synthetic peptide corresponding to a portion of GAD1. (Human)Application: GAD1 antibody can be used for detection of GAD1 by WB (5 µg/ml), IHC-parafin (10 µg/ml).Buffer: GAD1 antibody is supplied in PBS, 0.2% gelatin, 0.05% sodium azide.Storage: GAD1 antibody can be stored at 4ºC for short term storage, for long term storage aliquot and store at -20ºC . Avoid freeze thaw cycles.
Cite This Product ProSci cat# 49-276 RRID:AB_1946429
Company ProSci, Inc
Type Polyclonal Antibody
Isotype IgG