Chicken Anti-Glial Fibrillary Acidic Protein Polyclonal Antibody, U...

  • Chicken Anti-Glial Fibrillary Acidic Protein Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 50-268

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Target Glial fibrillary acidic protein
Species Cross Reactivity Homo sapiens, Mus musculus, Rattus norvegicus
Host Species Gallus gallus
Target Tag/Conjugate Unconjugated
Applications WB, IF
Unit 0.1 ml
Format Purification: Total IgY fraction
Description Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques. It was subsequently found to be a member of the 10nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers.Specificity: Specific for the ~50kDa GFAP protein. A lower band at ~45kDa is a proteolytic fragment derived from the GFAP molecule.Immunogen: Recombinant and purified bovine GFAP.Buffer: Glial Fibrillary Acidic Protein antibody is supplied as total IgG fraction.Storage: Glial Fibrillary Acidic Protein antibody can be stored at -20ºC and is stable at -20ºC for at least 1 year.
Cite This Product ProSci cat# 50-268 RRID:AB_1946519
Company ProSci, Inc
Type Polyclonal Antibody
Isotype IgY