Rabbit Anti-Grik Detection Set Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Grik Detection Set Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : PSI-1824

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Target GRIK
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB, IHC
Unit 1 Set
Description Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and Grik5/KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Grik2, also known as glutamate receptor 6, may be associated with autosomal recessive mental retardation and possibly other neurological disorders such as schizophrenia. Numerous isoforms of Grik2 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow. Grik3, also known as glutamate receptor 7, has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation. Grik4 codes for the KA1 subunit of kainate-type ionotropic gluatamate receptors; mutations in this gene show significant association with both schizophrenia and bipolar disorder. Grik5, also known as kainate-preferring glutamate receptor subunit KA2, does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface.Kit Contents: Grik1 Antibody (IN), Catalog No. 4381 (50µg) Grik2 Antibody (C2), Catalog No. 4387 (50µg) Grik3 Antibody, Catalog No. 4389 (50µg) Grik4 Antibody (CT), Catalog No. 4391 (50µg) Grik5 Antibody, Catalog No. 4397 (50µg)Source: Rabbit polyclonal antibodies were raised against peptides corresponding to amino acid sequences from each of the corresponding proteins. Blocking Peptide: Grik1 Peptide (IN), Catalog No. 4381P Grik2 Peptide (C2), Catalog No. 4387P Grik3 Peptide, Catalog No. 4311P Grik4 Peptide (CT), Catalog No. 4391P Grik5 Peptide, Catalog No. 4397P Positive Control: Grik1 Antibody: Rat Brain Lysate, Catalog No. 1463 Grik2 Antibody: Human Brain Lysate, Catalog No. 1303 Grik3 Antibody: Human Brain Tissue Lysate, Catalog No. 1303 Grik4 Antibody: Rat Brain Lysate, Catalog No. 1463Applications: These polyclonal antibodies can be used for detection of Grik1 – 5 by immunoblot at 1 – 2 µg/ml, and for detection of Grik1, 4 or 5 by immunohistochemistry at 2.5 µg/ml. Storage: Antibodies are supplied as affinity chromatography purified IgG, in PBS containing 0.02% sodium azide. Antibodies should be stored at -20ºC.
Cite This Product ProSci cat# PSI-1824 RRID:AB_1940322
Company ProSci, Inc
Type Polyclonal Antibody
Target/Molecule Descriptor Detection Set