Rabbit Anti-TSC1 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-TSC1 Polyclonal Antibody, Unconjugated

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    CatalogueID : 3505

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Target Tsc1
Species Cross Reactivity Rattus norvegicus, Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, ICC, WB, IF
Target Species Homo sapiens
Target/Molecule Synonym TSC1 Antibody: Tuberous sclerosis complex 1, Hamartin
Format TSC1 Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
NCBI Gene Aliases LAM, TSC, MGC86987, KIAA0243
Description TSC1 Antibody: Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown
Cite This Product ProSci cat# 3505 RRID:AB_735774
Company ProSci
Type Antibody
Accession Number AAC51674
Immunogen TSC1 antibody was raised against a 15 amino acid synthetic peptide from the middle region of human TSC1. TSC1 antibody will recognize both isoforms of TSC1
Isotype IgG
Molecule Name TSC1 tuberous sclerosis 1
Clonality Polyclonal