Rabbit Anti-Mouse Heparanase Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Mouse Heparanase Polyclonal Antibody, Unconjugated

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    CatalogueID : 49-929

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Target Heparanase
Species Cross Reactivity Mus musculus
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB, IHC
Target Species Mus musculus
Target/Molecule Synonym HPSE, EC 3.2.-.-, HEP, HEPARANASE-1, HPA, HPA1, HPR1, HPSE1, HSE1
Unit 0.05 mg
Format Purification: Protein G ColumnFormulation: Weight: 50 µg
Description Heparanase is an endo-beta-D-glucuronidase, which degrades heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasation of tumor cells and inflammatory leukocytes. Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis. Heparanase is a heterodimer comprised of a 50kD subunit harboring the active site and a 8kD subunit. It is produced as a latent 65kD precursor and proteolytically processed to its active form. Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in platelets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors, correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival. Suitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested. Reacts with the 65kD precursor as well as the 50kD and 8kD subunits of human or mouse Heparanase.Immunogen: Heparanase antibody was raised against 50kD-8kD Heparanase heterodimer. (Human)Application: Heparanase antibody can be used for detection of Heparanase by WB (minimum working dilution: 1:500 maximum working dilution: 1:500), IHC-parafin (minimum working concentration: 5 µg/ml).Buffer: Heparanase antibody is supplied in 20 mM sodium phosphate, 150 mM sodium chloride, pH 7.2, 0.01% Thimerosal.Storage: Heparanase antibody can be stored at 4ºC or -20ºC. Avoid repeated freezing and thawing.
Cite This Product ProSci cat# 49-929 RRID:AB_1946739
Company ProSci, Inc
Type Polyclonal Antibody
Isotype IgG