Rabbit Anti-AR Polyclonal Antibody, Unconjugated

  • Rabbit Anti-AR Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 49-155

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Target AR
Species Cross Reactivity Mus musculus, Rattus norvegicus
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB, IHC
Target/Molecule Synonym AR, AIS, DHTR, HUMARA, KD, NR3C4, SBMA, SMAX1, TFM, Androgen receptor, Dihydrotestosterone receptor, nr3c4
Unit 0.05 mg
Format Purification: Immunoaffinity ChromatographyFormulation: Weight: 50 µg
Description The androgen receptor (AR) is a NR3 Steroid Receptor located on the X chromosome. AR is a phosphoprotein and acts as a steroid hormone-activated transcription factor for andogen-responsive genes. Mutations in the AR gene are associated with androgen insensitivity syndrome (CAIS) or testicular feminization syndrome, Reifenstein syndrome, and Kennedy spinal and bulbar muscular atrophy. They lead to symptoms such as low virilization, reduced sperm production, testicular atrophy, and infertility. Androgen signaling through the androgen receptor (AR) appears to be involved in all aspects of prostate cancer, from initiation to development of treatment resistance. Gain-of-function AR gene mutations and/or altered signaling through AR have been suggested to contribute to disease progression. A recent study showed decreased expression of AR in response to incubation of LNCaP prostate carcinoma cells with PC-SPES, a mixture of eight herbs (Bonham et al. 2002). Two forms of AR that differ in their N termini have been isolated: AR A (87 kDa), which is derived from translation of an internal methionine codon (met188), and AR B (110 kDa). The two isoforms are expressed in similar tissues; however, AR B generally is the more abundant form.Immunogen: AR antibody was raised against a synthetic peptide corresponding to N-terminal residues of AR. (Human)Application: AR antibody can be used for detection of AR by WB (2.5 - 5 µg/ml), IHC-parafin (10 µg/ml).Buffer: AR antibody is supplied in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.Storage: AR antibody can be stored at 4ºC, avoid freezing.
Cite This Product ProSci cat# 49-155 RRID:AB_1945161
Company ProSci, Inc
Type Polyclonal Antibody
Uniprot ID P49699