Rabbit Anti-Monkey GNAS Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Monkey GNAS Polyclonal Antibody, Unconjugated

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    CatalogueID : 48-427

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Target GNAS
Species Cross Reactivity Monkey (Species unspecified)
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, IHC
Target Species Monkey (Species unspecified)
Target/Molecule Synonym GNAS, AHO, C20ORF45, CARD3, DJ309F20.1.1, DJ806M20.3.3, GNAS1, GNASXL, GPSA, GSA, GSP, MGC33735, NESP, NESP55, PHP1A, PHP1B, POH, SCG6, XL, XL2, XLALPHAS, adenylate cyclase-stimulating g alpha protein, gnas, gnas1, guanine nucleotide-binding protein g(s), alpha subunit
Unit 0.05 mg
Format Purification: Protein G ColumnFormulation: Weight: 50 µg Volume: 50 µl Concentration: 1 mg/ml
Description The GNAS1 gene encodes the alpha subunit of the G protein Gs, which couples receptor binding by several hormones to activation of adenylate cyclase (Hayward et al., 1998). This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript exists, and this antisense transcript and one of the transcripts are paternally expressed, produce noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.Immunogen: GNAS antibody was raised against amino acids 385 to 394 of GNAS. (Human)Application: GNAS antibody can be used for detection of GNAS by ELISA (1:0 - 1:1000), IHC-parafin (20 µg/ml).Buffer: GNAS antibody is supplied in PBS, 0.1% sodium azide.Storage: GNAS antibody can be stored at -20ºC for long term storage, and 4ºC for short term storage.
Cite This Product ProSci cat# 48-427 RRID:AB_1946540
Company ProSci, Inc
Type Polyclonal Antibody