Rabbit Anti-GBL Polyclonal Antibody, Unconjugated

  • Rabbit Anti-GBL Polyclonal Antibody, Unconjugated

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    CatalogueID : 3495

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Target mLST8
Species Cross Reactivity Rattus norvegicus, Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC, IF
Target Species Homo sapiens
Target/Molecule Synonym GBL Antibody: G beta protein subunit-like
Format GBL Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
NCBI Gene Aliases GBL, GbetaL, POP3, MGC111011, LST8, WAT1
Description GBL Antibody: GbetaL (G protein beta protein subunit-like) is a member of a signaling pathway that regulates mammalian cell growth in response to the presence of nutrients and growth factors. It binds to the kinase domain of TOR (Target of rapamycin, also known as mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. Rapamycin inhibits TOR resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation. TOR is normally associated with GbetaL and an additional regulatory protein RAPTOR, allowing TOR to control protein biosynthesis. The binding of GbetaL to TOR stimulates TOR's kinase activity towards downstream proteins such as RPS6K (ribosomal protein S6 kinase) and the translation factor 4E-BP1 which leads to increased protein translation and cell growth
Cite This Product ProSci cat# 3495 RRID:AB_735741
Company ProSci
Type Antibody
Accession Number AAH52292
Immunogen GbL antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human GbL
Isotype IgG
Molecule Name G protein beta subunit-like
Clonality Polyclonal