Rabbit Anti-GAT-1 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-GAT-1 Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 50-215

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Target GAT-1
Species Cross Reactivity Mus musculus, Rattus norvegicus
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB
Unit 0.1 ml
Format Purification: Affinity purified
Description Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003).Immunogen: Peptide corresponding to amino acid residues from the C-terminal region of rat GAT-1.Application: The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will also react with mouse tissue based on the fact that this species has 100% homology with the amino acid sequence used as antigen.Buffer: GAT-1 antibody is supplied as affinity purified polyclonal antibody, 100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.Storage: GAT-1 antibody can be stored at -20ºC and is stable at -20ºC for at least 1 year.
Cite This Product ProSci cat# 50-215 RRID:AB_1946450
Company ProSci, Inc
Type Polyclonal Antibody