Rabbit Anti-Caspase-4 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Caspase-4 Polyclonal Antibody, Unconjugated

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    CatalogueID : 3451

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Target metS
Species Cross Reactivity Archaea (Species unspecified), Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB, IHC, IF
Target Species Homo sapiens
Target/Molecule Synonym Caspase-4 Antibody: ICH-2, ICE rel II, Mih1
Format Caspase-4 Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
NCBI Gene Aliases Mih1/TX, TX, ICH-2, ICE(rel)II, ICEREL-II
Description Caspase-4 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18. Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells. More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer's disease
Cite This Product ProSci cat# 3451 RRID:AB_735336
Company ProSci
Type Antibody
Accession Number AAA86890
Immunogen Caspase-4 antibody was raised against a 16 amino acid synthetic peptide from the amino-terminus of human Caspase-4
Isotype IgG
Molecule Name CASP4 caspase 4, apoptosis-related cysteine peptidase
Clonality Polyclonal