Rabbit Anti-Mouse Caspase-4 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Mouse Caspase-4 Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 49-582

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Target Caspase-4
Species Cross Reactivity Mus musculus
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB, IHC
Target Species Mus musculus
Target/Molecule Synonym CASP4, CASP-4, EC 3.4.22.-, ICE, ICE(REL)II, ICEREL-II, ICH-2, ICH2, MIH1/TX, RELII), TX, casp4, caspase 4, cysteine protease icerel-ii, ICErel-II, ich-2, tx protease
Unit 0.05 mg
Format Purification: Immunoaffinity ChromatographyFormulation: Weight: 50 µg Concentration: 1 mg/ml
Description Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1b and IL-18. Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells. More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer’s disease. The rodent homolog is known as Caspase 4 and Caspase 11.Immunogen: HumanApplication: Caspase-4 antibody can be used for detection of Caspase-4 by WB, IHC-parafin (5 µg/ml).Buffer: Caspase-4 antibody is supplied in PBS, 0.02% sodium azide.Storage: Caspase-4 antibody can be stored at should be aliquoted and then store at -20ºC. Minimize freezing and thawing.
Cite This Product ProSci cat# 49-582 RRID:AB_1945492
Company ProSci, Inc
Type Polyclonal Antibody