Rabbit Anti-Caspase-5 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Caspase-5 Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 51-141

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Target Caspase-5
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB, IHC
Target/Molecule Synonym CASP5, casp5, caspase-5, icerel-iii, ICH-3, TY protease
Unit 0.05 mg
Format Purification: Protein G ColumnFormulation: Weight: 50 µg Concentration: 0.5 mg/ml
Description Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase-5 contains the absolutely conserved pentapeptide sequence Gln-Ala-Cys-Arg-Asp encompassing the catalytic cysteine residue. It is also a larger proenzymes, compared to Caspase-1, which are proteolytically processed to form heterodimeric active enzymes. Caspase-5 is suggested as a new target gene in the microsatellite mutator pathway for cancer.Immunogen: Antibody was raised against a synthetic peptide corresponding to amino acids 159-176 and 383-399 of human Caspase-5. (Human)Application: Caspase-5 antibody can be used for detection of Caspase-5 by WB (1 - 3 µg/ml), IHC-parafin (5 µg/ml).Buffer: Antibody is supplied in PBS, 0.2% gelatin, 0.02% sodium azide.Storage: Antibody can be stored at 4ºC for short term storage, and -20ºC for long term storage. Avoid repeated freezing and thawing.
Cite This Product ProSci cat# 51-141 RRID:AB_1945493
Company ProSci, Inc
Type Polyclonal Antibody
Isotype IgG