Rabbit Anti-Caspase-8 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Caspase-8 Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 49-788

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Target Caspase-8
Species Cross Reactivity Mus musculus, Rattus norvegicus, Bos taurus, Monkey (Species unspecified)
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB, IHC, IP
Target/Molecule Synonym CASP8, CAP4, CASP-8, EC 3.4.22.-, FLICE, MACH, MCH5, MGC78473, casp8, caspase 8, FADD-HOMOLOGOUS ICE/CED3-LIKE PROTEASE, FADD-LIKE ICE, FADD-like interleukin-1beta-converting enzyme, Fas-associated death domain-like IL-1-converting enzyme, ICE-like apoptotic protease 5, MORT1-ASSOCIATED CED3 HOMOLOG
Unit 0.05 mg
Format Purification: Protein A ColumnFormulation: Volume: 50 µl
Description Also available with BSA and azide. See LS-C12527Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex. The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation. FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis.Immunogen: Caspase-8 antibody was raised against recombinant Caspase-8. (Human)Application: Caspase-8 antibody can be used for detection of Caspase-8 by WB, IP, IHC-parafin (minimum working concentration: 5 µg/ml).Buffer: Caspase-8 antibody is supplied in 10 mM PBS, pH 7.4.Storage: Caspase-8 antibody can be stored at 4ºC for short term storage, and -20ºC with 40-50% glycerol for long term storage.
Cite This Product ProSci cat# 49-788 RRID:AB_1945496
Company ProSci, Inc
Type Polyclonal Antibody
Isotype IgG