Rabbit Anti-Caspase-8 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-Caspase-8 Polyclonal Antibody, Unconjugated

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    CatalogueID : 3475

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Target Casp8
Species Cross Reactivity Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications EIA, WB
Target Species Homo sapiens
Target/Molecule Synonym Caspase-8 Antibody: FLICE, MACH, Mch5
Format Caspase-8 Antibody is supplied in PBS containing 0.02% sodium azide., Liquid
Concentration 1 mg/mL
NCBI Gene Aliases FLJ17672, Casp-8, CAP4, FLICE, MGC78473, MCH5, ALPS2B, MACH
Description Caspase-8 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex. The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation. FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis. This antibody will only detect isoform E of caspase-8
Cite This Product ProSci cat# 3475 RRID:AB_735337
Company ProSci
Type Antibody
Accession Number NP_001219
Immunogen Caspase-8 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus human caspase-8 isoform E
Isotype IgG
Molecule Name CASP8 caspase 8, apoptosis-related cysteine peptidase
Clonality Polyclonal