Rabbit Anti-GPR65 Polyclonal Antibody, Unconjugated

  • Rabbit Anti-GPR65 Polyclonal Antibody, Unconjugated

    from ProSci
    CatalogueID : 48-925

  • Contact Vendor

Target Gpr65
Species Cross Reactivity Mus musculus, Rattus norvegicus, Canis lupus familiaris, Monkey (Species unspecified)
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB, IHC
Target/Molecule Synonym GPR65, HTDAG8, TDAG8, g protein-coupled receptor 65, g protein-coupled receptor tdag8, Gpcr25, gpr65, htdag8, psychosine receptor, t-cell death-associated gene 8, tdag8
Unit 0.05 mg
Format Purification: Immunoaffinity ChromatographyFormulation: Weight: 50 µg Concentration: 0.5 mg/ml
Description GPR65 (TDAG8), a Lysophospholipid/Lysosphingolipid Receptor, is a molecular target for psychosine, a toxic lipid formed by the breakdown of galactosylceramide (cerebroside). A build-up of psychosine, caused by the lack of galactosylceramidase, results in the death of the myelin-synthesizing cells, oligodendrocytes, which is associated with Krabbe disease. Recent evidence suggests that GPR65 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine and its related lysosphingolipids behave as if they were antagonists against protein-sensing receptors, including TDAG8, GPR4 and OGR1 (Wang et al. 2004.)Immunogen: GPR65 antibody was raised against a portion of amino acids 200-250 of GPR65. (Human)Application: GPR65 antibody can be used for detection of GPR65 by WB (0.5 - 2 µg/ml), IHC-parafin (20 µg/ml).Buffer: GPR65 antibody is supplied in PBS, 0.2% gelatin, 0.05% sodium azide.Storage: GPR65 antibody can be stored at 4ºC for short term storage, for long term storage aliquot and store at -20ºC . Avoid freeze thaw cycles.
Cite This Product ProSci cat# 48-925 RRID:AB_1946616
Company ProSci, Inc
Type Polyclonal Antibody