Rabbit Anti-Human Histone Deacetylase 3 Polyclonal Antibody, Unconj...

  • Rabbit Anti-Human Histone Deacetylase 3 Polyclonal Antibody, Unconjugated

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    CatalogueID : 49-281

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Target Histone deacetylase 3
Species Cross Reactivity Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications WB, IHC, IP
Target Species Homo sapiens
Target/Molecule Synonym HDAC3, HD3, RPD3, RPD3-2, SMAP45, hdac3, histone deacetylase 3
Unit 0.05 mg
Format Purification: Protein G ColumnFormulation: Weight: 50 µg Concentration: 0.5 mg/ml
Description Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.Immunogen: Histone Deacetylase 3 antibody was raised against a synthetic peptide corresponding to amino acids 2-17 of Histone Deacetylase 3. (Human)Application: Histone Deacetylase 3 antibody can be used for detection of Histone Deacetylase 3 by WB (2 µg/ml), IP, IHC-parafin (10 µg/ml), ChrIP.Buffer: Histone Deacetylase 3 antibody is supplied in PBS, 0.2% gelatin, 0.05% sodium azide.Storage: Histone Deacetylase 3 antibody can be stored at 4ºC for short term storage, for long term storage aliquot and store at -20ºC . Avoid freeze thaw cycles.
Cite This Product ProSci cat# 49-281 RRID:AB_1946841
Company ProSci, Inc
Type Polyclonal Antibody
Isotype IgG