Rabbit Anti-MTA2 Polyclonal Antibody

  • Rabbit Anti-MTA2 Polyclonal Antibody

    CatalogueID : bs-9440R

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Target MTA2
Species Cross Reactivity Rattus norvegicus, Mus musculus, Homo sapiens
Host Species Oryctolagus cuniculus
Target Tag/Conjugate Unconjugated
Applications IHC, IHC-Fr, EIA, WB, IF
Unit 100 ug Lyophilized
Format 1ug/uL, Two additional vials are included in shipment for reconstitution purposes (double distilled H20 and sterile glycerol). Centrifuge all vials to ensure necessary quantities have settled. Add 50uL of sterile double distilled water to antibody. Mix thoroughly by gently pipetting up and down. Then, add 50uL of sterile glycerol to antibody. Mix well and keep cold., *Please note lyophilized powder is supplied in bovine serum albumin and sodium azide. After reconstitution, final concentration of preservatives are 10ug/uL BSA and 0.1% NaN3
Concentration 1ug/uL
NCBI Gene Aliases Mata1l1;, Metastasis associated 1 family member 2;, Metastasis associated 1 like 1;, Metastasis associated gene 1 like 1;, Metastasis associated gene family member 2;, Metastasis associated protein 2;, Metastasis associated protein MTA 2;, Metastasis associated protein MTA2;, Mmta2;, MTA1 L1 protein;, MTA1-L1 protein;, MTA1L1;, MTA1L1: metastasis-associated 1-like 1;, P53 target protein in deacetylase complex;, PID
Description MTA1 is a component of the NURD (nucleosome remodeling and histone deacetylation) complex, which is associated with ATP-dependent chromatin-remodeling and histone deacetylase activity. MTA1 functions in conjunction with other components of NURD to mediate transcriptional repression as it facilitates the association of repressor molecules with the chromatin. Structurally, MTA1 contains a single SH3-binding motif and a zinc finger domain, along with a region similar to the co-repressor protein N-Cor. MTA1 is normally expressed at low levels in various tissues and is more highly expressed in testis. Overexpression of MTA1 correlates with tumor invasion and metastasis in various carcinomas including colorectal, gastrointestinal and breast carcinomas. Elevation of MTA1 levels in these tumors appears to enhance the metastases to lymph nodes, increase mammary cell motility and potentiate growth, and therefore may be an indicator for assessing the potential malignancies of various tumors. A similar protein, MTA2, also designated MTA1-L1 (MTA1-like protein 1), shares more than 55% sequence homology with MTA1 and is ubiquitously expressed
Company Bioss
Type Antibody
Immunogen KLH conjugated synthetic peptide derived from human MTA2
Isotype IgG
Molecular Weight 75kDa
Purity Was purified by Protein A and peptide affinity chromatography